Important Safety Information

RAPTIVA® (efalizumab) is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Like any prescription medication, RAPTIVA is not for everyone. You should not use RAPTIVA if you are allergic to any of its ingredients.

RAPTIVA is an immunosuppressive agent. Many immunosuppressive agents can decrease the activity of the immune system and have the potential to increase the risk of infection and cancer. However, the role of RAPTIVA in the development of cancer is not known.

Low platelet counts (thrombocytopenia) have been infrequently observed (in 0.3% of clinical trial patients) during treatment. Platelets help your blood clot. Call your doctor right away if you notice unusual or easy bruising or bleeding. Your healthcare provider may test your platelet counts.

Low blood counts (anemia) may occur, so call your doctor right away if you feel weak, light-headed, or notice a change of color to your skin, eyes, or urine.

Some patients (0.7% in clinical trials) have had serious worsening or new forms of psoriasis while taking RAPTIVA or after stopping RAPTIVA. Tell your healthcare provider right away if your psoriasis gets worse or if you see any new rashes during or after treatment with RAPTIVA. You should not stop treatment until you've talked with your healthcare provider.

Some patients have had worsening or new arthritis while taking RAPTIVA or after stopping RAPTIVA. Tell your healthcare provider if you experience joint pain or stiffness.

Remember to monitor any new symptoms you may experience while taking RAPTIVA and discuss any concerns with your doctor.

See your healthcare provider before taking any vaccines while taking RAPTIVA.

The most common side effects of RAPTIVA include headache, chills, fever, nausea, and muscle aches. These reactions usually happen within the first 48 hours following a RAPTIVA injection and often decrease after the first few weeks of use of RAPTIVA. Back pain or swelling of the arms or legs (peripheral edema) can also happen with RAPTIVA.

Tell your healthcare provider if you are pregnant or plan to become pregnant and ask about the RAPTIVA pregnancy registry. Or find out more by calling 1-877-RAPTIVA to enroll.

Please see accompanying full Prescribing Information.